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Ozempic (sold as Wegovy for weight loss) is a version of GLP-1 that resists that rapid breakdown, so it circulates in the blood for up to a week at far higher levels than natural GLP-1
There is an increased risk of hypoglycemia when JANUVIA is added to an insulin secretagogue (e.g., sulfonylurea) or insulin therapy
A noninferiority trial compared sitagliptin to glipizide as add-on therapy in 1,172 patients inadequately controlled using metformin alone
BMJ 384 , e076410076410 (2024)
GLP #2 has also demonstrated success over the long term
"Medi-Cal Rx Contract Drugs List Update: GLP-1 Coverage Changes Effective January 1, 2026." Wegovy, Zepbound, and Saxenda removed from CDL for weight loss indications
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